Fig. 1

Comparison of genome-wide distribution between 5mC and 5hmC. a Boxplot of the total number of the 5mC peaks and 5hmC peaks in PDAC samples. b Enrichment analysis of the 5mC and 5hmC peaks overlapping with distinct genomic elements. c Metagene profiles of the regions from TSS to TES with the flanking 3 kb. Boxplots of Log₂ (odds ratio) of peaks overlapping with H3K36me3 (d), H3K27ac (e), H3K4me1 (f), H3K27me3 (g), and H3K4me3 (h). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 1e−5, Wilcoxon test. PDAC, pancreatic ductal adenocarcinoma; TSS, transcription start sites; TES, transcription end sites