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Table 2 Associations between histone methylation marks and clinicopathologic parameters in various cancer types

From: Clinicopathologic significance of protein lysine methyltransferases in cancer

H3K4me2
Cancer type Clinicopathologic association
Non-small cell lung cancer [47, 48]
Pancreatic adenocarcinoma [47]
Colorectal cancer [47]
Esophageal squamous cell carcinoma [47]
Hepatocellular carcinoma [47]
Cervical cancer [47]
Prostate cancer [49]
Renal cell carcinoma [48]
Lower H3K4me2 correlates with worse survival
H3K4me3
Cancer type Clinicopathologic association
Non-small cell lung cancer [47]
Pancreatic adenocarcinoma [47]
Colorectal cancer [47, 50]
Esophageal squamous cell carcinoma [47]
Hepatocellular carcinoma [47, 51]
Cervical cancer [47]
Higher H3K4me3 correlates with worse survival
H3K27me3
Cancer type Clinicopathologic association
Colorectal cancer [52] Higher H3K27me3 correlates with poor survival
Hepatocellular carcinoma [53] Higher H3K27me3 correlates with larger tumor size, poorly differentiated tumors, advanced clinical stage, vascular invasion, and poor survival
Esophageal squamous cell carcinoma [54, 55] Higher H3K27me3 correlates with advanced TNM stage and poor survival
Gastric cancer [56] Higher H3K27me3 correlates with poorly differentiated tumors, distant metastasis and poor survival
Breast cancer [57, 58] Higher H3K27me3 correlates with lower tumor grade and better survival
Non-small cell lung cancer [59] Higher H3K27me3 correlates with better survival
H3K36me3
Cancer type Clinicopathologic association
Hepatocellular carcinoma [60] Higher H3K36me3 correlates with higher tumor grade, advanced TNM stage and worse survival
Renal cell carcinoma [61] Lower H3K36me3 correlates with worse survival
H3K9me3
Cancer type Clinicopathologic association
Colorectal cancer [62] Higher H3K9me3 correlates with lymph node metastasis
Gastric cancer [56, 63] Higher H3K9me3 correlates with advanced tumor stage, lymphovascular invasion and worse survival
Non-small cell lung cancer [64] Higher H3K9me3 correlates with tumor recurrence
Esophageal squamous cell carcinoma [65] Higher H3K9me3 correlates with worse survival