Table 2 Associations between histone methylation marks and clinicopathologic parameters in various cancer types
From: Clinicopathologic significance of protein lysine methyltransferases in cancer
H3K4me2 | |
Cancer type | Clinicopathologic association |
Non-small cell lung cancer [47, 48] Pancreatic adenocarcinoma [47] Colorectal cancer [47] Esophageal squamous cell carcinoma [47] Hepatocellular carcinoma [47] Cervical cancer [47] Prostate cancer [49] Renal cell carcinoma [48] | Lower H3K4me2 correlates with worse survival |
H3K4me3 | |
Cancer type | Clinicopathologic association |
Non-small cell lung cancer [47] Pancreatic adenocarcinoma [47] Esophageal squamous cell carcinoma [47] Hepatocellular carcinoma [47, 51] Cervical cancer [47] | Higher H3K4me3 correlates with worse survival |
H3K27me3 | |
Cancer type | Clinicopathologic association |
Colorectal cancer [52] | Higher H3K27me3 correlates with poor survival |
Hepatocellular carcinoma [53] | Higher H3K27me3 correlates with larger tumor size, poorly differentiated tumors, advanced clinical stage, vascular invasion, and poor survival |
Higher H3K27me3 correlates with advanced TNM stage and poor survival | |
Gastric cancer [56] | Higher H3K27me3 correlates with poorly differentiated tumors, distant metastasis and poor survival |
Higher H3K27me3 correlates with lower tumor grade and better survival | |
Non-small cell lung cancer [59] | Higher H3K27me3 correlates with better survival |
H3K36me3 | |
Cancer type | Clinicopathologic association |
Hepatocellular carcinoma [60] | Higher H3K36me3 correlates with higher tumor grade, advanced TNM stage and worse survival |
Renal cell carcinoma [61] | Lower H3K36me3 correlates with worse survival |
H3K9me3 | |
Cancer type | Clinicopathologic association |
Colorectal cancer [62] | Higher H3K9me3 correlates with lymph node metastasis |
Higher H3K9me3 correlates with advanced tumor stage, lymphovascular invasion and worse survival | |
Non-small cell lung cancer [64] | Higher H3K9me3 correlates with tumor recurrence |
Esophageal squamous cell carcinoma [65] | Higher H3K9me3 correlates with worse survival |