Fig. 3

Correlation analysis of H3K27ac ChIP-seq data, RNAPII ChIP-seq data, and RNA-seq data. a Correlation between H3K27ac ChIP-seq vs. RNAPII ChIP-seq data (left plot) and RNA-seq data (right plot) in the same sample, respectively. H3K27ac ChIP-seq data is presented on the y-axis, whereas RNAPII ChIP-seq data and RNA-seq data are shown on the x-axis and z-axis (log₂ scale). b Correlation between annotated genes from differentially acetylated regions and differentially expressed genes from transcriptome profiles from our study and two published studies. Differentially expressed genes per study are ranked by their fold changes and shown on the x-axis. The running correlation throughout the gene set is shown by the curve (green) and the running enrichment score (ES) is shown in the y-axis. Enrichment score normalized for gene set size (NES) and the false discovery rate (FDR) are shown above each plot. Black bars indicate annotated genes from differentially acetylated regions that are presented among the transcriptome profiles