Fig. 2

Distribution of tandem regulated chromatin domains (TRCDs). a Manhattan plot depicting the distribution of differentially H3K27 acetylated regions in patients vs. controls: non-significant regions (grey), hyperacetylated regions (aqua), and hypoacetylated regions (coral). b Zoomed-in view of clusters of TRCDs in the short range (indicated with the bar with higher acetylation level in patients than in controls on chromosome 10). c Zoomed-in view of clusters of TRCDs in the short range (indicated with the bar) with lower acetylation level in patients than in controls on chromosome 6. d Number of identified active and repressed TRCDs in short- and long-genomic distance respectively in real and randomly distributed dataset