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Table 3 PFASs—significant adjusted differences (BACON-corrected FDR p values < 0.05) in placenta DNA methylation associated with maternal plasma concentration of PFASs (n = 262)

From: Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation

Chemicals

CpG

Gene

logFC

[95% CI]

BACON-corrected p value

BACON-corrected FDR p value

PFDA

cg04117229

SPG20

− 0.61

[− 0.78, − 0.45]

6.57E−10

2.69E−04

cg23851558

LOC400940

− 0.16

[− 0.20, − 0.11]

4.83E−08

9.88E−03

cg14355889

MYO18A

− 0.07

[− 0.09, − 0.05]

7.36E−08

1.00E−02

cg09441069

FTCD

− 0.09

[− 0.12, − 0.06]

2.46E−07

2.30E−02

cg06858599

SNRPG

− 0.16

[− 0.22, − 0.11]

2.81E−07

2.30E−02

cg13746315

MCTP2*

− 1.05

[− 1.41, − 0.69]

8.39E−07

4.80E−02

cg01352468

ANKRD13B

− 0.31

[− 0.41, − 0.20]

9.19E−07

4.80E−02

cg07471462

SLC39A7

− 0.21

[− 0.28, − 0.14]

1.11E−06

4.80E−02

cg23317906

TMX1

− 0.15

[− 0.20, − 0.10]

1.20E−06

4.80E−02

cg18844176

MTHFD1

− 0.33

[− 0.45, − 0.22]

1.21E−06

4.80E−02

cg08912652

SNX19

− 0.33

[− 0.44, − 0.21]

1.41E−06

4.80E−02

cg10391212

CORIN

0.06

[0.04, 0.08]

1.41E−06

4.80E−02

cg13006259

MYL6B

− 0.63

[− 0.85, − 0.41]

1.64E−06

4.80E−02

cg07169834

RDM1

0.11

[0.07, 0.15]

1.55E−06

4.80E−02

PFHxS

cg21058927

CISD2

− 0.54

[− 0.71, − 0.37]

1.06E−07

4.12E−02

cg11428546

AFF3

− 0.04

[− 0.05, − 0.03]

2.39E−07

4.12E−02

cg10530492

NOL7

− 0.12

[− 0.16, − 0.08]

3.02E−07

4.12E−02

PFNA

cg26808417

ARL8A

− 0.10

[− 0.13, − 0.07]

6.00E−08

2.45E−02

cg21502999

ELK3

0.31

[0.21, 0.41]

2.40E−07

4.91E−02

PFOS

cg17921248

PRKCA

0.06

[0.05, 0.08]

1.43E−08

5.84E−03

cg11891579

EBF1

0.16

[0.11, 0.21]

4.53E−08

9.27E−03

cg01954404

SERPINA1*

− 0.10

[− 0.14, − 0.07]

7.22E−08

9.85E−03

PFUnDA

cg13996963

TUSC3

0.39

[0.27, 0.51]

8.83E−09

3.61E−03

cg12599971

GRAMD3*

− 0.42

[− 0.55, − 0.29]

4.49E−08

9.18E−03

cg15719126

MAPK8IP1

− 0.22

[− 0.29, − 0.15]

8.72E−08

1.10E−02

cg13705616

SHANK2

0.18

[0.12, 0.24]

1.07E−07

1.10E−02

cg12089439

TUSC3

0.40

[0.27, 0.53]

1.92E−07

1.37E−02

cg18145877

TUSC3

0.63

[0.42, 0.84]

2.01E−07

1.37E−02

cg08912652

SNX19

− 0.41

[− 0.55, − 0.27]

4.91E−07

2.87E−02

cg03223126

CUX2

− 0.34

[− 0.46, − 0.22]

7.32E−07

3.34E−02

cg16347018

ATP5E

− 1.10

[− 1.49, − 0.72]

7.35E−07

3.34E−02

cg14067524

MYO16

− 0.29

[− 0.39, − 0.18]

1.13E−06

4.38E−02

cg10058241

DOC2B

0.17

[0.11, 0.23]

1.32E−06

4.38E−02

cg09442654

FAM150A

0.55

[0.35, 0.75]

1.40E−06

4.38E−02

cg07471462

SLC39A7

− 0.24

[− 0.33, − 0.15]

1.50E−06

4.38E−02

cg10550693

SYVN1

0.07

[0.04, 0.09]

1.43E−06

4.38E−02

cg24722365

KIF1B

− 0.14

[− 0.19, − 0.09]

1.61E−06

4.38E−02

cg18336854

TUSC3

− 0.18

[− 0.24, − 0.11]

1.79E−06

4.58E−02

cg24298878

ILF3

− 1.22

[− 1.67, − 0.78]

1.98E−06

4.76E−02

  1. Adjusted for maternal self-reported race/ethnicity, maternal age in years, fetal sex, maternal pre-pregnancy BMI, cotinine level, methylation sample plate, first three methylation principal component (PCs), the first 10 genotype PCs and Surrogate Variable Analysis (SVA).
  2. logFC logarithm of fold change, FDR false discovery rate
  3. *Annotation from the nearest gene