Table 3 PFASs—significant adjusted differences (BACON-corrected FDR p values < 0.05) in placenta DNA methylation associated with maternal plasma concentration of PFASs (n = 262)

PFDA

cg04117229

SPG20

− 0.61

[− 0.78, − 0.45]

6.57E−10

2.69E−04

cg23851558

LOC400940

− 0.16

[− 0.20, − 0.11]

4.83E−08

9.88E−03

cg14355889

MYO18A

− 0.07

[− 0.09, − 0.05]

7.36E−08

1.00E−02

cg09441069

FTCD

− 0.09

[− 0.12, − 0.06]

2.46E−07

2.30E−02

cg06858599

SNRPG

− 0.16

[− 0.22, − 0.11]

2.81E−07

2.30E−02

cg13746315

MCTP2*

− 1.05

[− 1.41, − 0.69]

8.39E−07

4.80E−02

cg01352468

ANKRD13B

− 0.31

[− 0.41, − 0.20]

9.19E−07

4.80E−02

cg07471462

SLC39A7

− 0.21

[− 0.28, − 0.14]

1.11E−06

4.80E−02

cg23317906

TMX1

− 0.15

[− 0.20, − 0.10]

1.20E−06

4.80E−02

cg18844176

MTHFD1

− 0.33

[− 0.45, − 0.22]

1.21E−06

4.80E−02

cg08912652

SNX19

− 0.33

[− 0.44, − 0.21]

1.41E−06

4.80E−02

cg10391212

CORIN

0.06

[0.04, 0.08]

1.41E−06

4.80E−02

cg13006259

MYL6B

− 0.63

[− 0.85, − 0.41]

1.64E−06

4.80E−02

cg07169834

RDM1

0.11

[0.07, 0.15]

1.55E−06

4.80E−02

PFHxS

cg21058927

CISD2

− 0.54

[− 0.71, − 0.37]

1.06E−07

4.12E−02

cg11428546

AFF3

− 0.04

[− 0.05, − 0.03]

2.39E−07

4.12E−02

cg10530492

NOL7

− 0.12

[− 0.16, − 0.08]

3.02E−07

4.12E−02

PFNA

cg26808417

ARL8A

− 0.10

[− 0.13, − 0.07]

6.00E−08

2.45E−02

cg21502999

ELK3

0.31

[0.21, 0.41]

2.40E−07

4.91E−02

PFOS

cg17921248

PRKCA

0.06

[0.05, 0.08]

1.43E−08

5.84E−03

cg11891579

EBF1

0.16

[0.11, 0.21]

4.53E−08

9.27E−03

cg01954404

SERPINA1*

− 0.10

[− 0.14, − 0.07]

7.22E−08

9.85E−03

PFUnDA

cg13996963

TUSC3

0.39

[0.27, 0.51]

8.83E−09

3.61E−03

cg12599971

GRAMD3*

− 0.42

[− 0.55, − 0.29]

4.49E−08

9.18E−03

cg15719126

MAPK8IP1

− 0.22

[− 0.29, − 0.15]

8.72E−08

1.10E−02

cg13705616

SHANK2

0.18

[0.12, 0.24]

1.07E−07

1.10E−02

cg12089439

TUSC3

0.40

[0.27, 0.53]

1.92E−07

1.37E−02

cg18145877

TUSC3

0.63

[0.42, 0.84]

2.01E−07

1.37E−02

cg08912652

SNX19

− 0.41

[− 0.55, − 0.27]

4.91E−07

2.87E−02

cg03223126

CUX2

− 0.34

[− 0.46, − 0.22]

7.32E−07

3.34E−02

cg16347018

ATP5E

− 1.10

[− 1.49, − 0.72]

7.35E−07

3.34E−02

cg14067524

MYO16

− 0.29

[− 0.39, − 0.18]

1.13E−06

4.38E−02

cg10058241

DOC2B

0.17

[0.11, 0.23]

1.32E−06

4.38E−02

cg09442654

FAM150A

0.55

[0.35, 0.75]

1.40E−06

4.38E−02

cg07471462

SLC39A7

− 0.24

[− 0.33, − 0.15]

1.50E−06

4.38E−02

cg10550693

SYVN1

0.07

[0.04, 0.09]

1.43E−06

4.38E−02

cg24722365

KIF1B

− 0.14

[− 0.19, − 0.09]

1.61E−06

4.38E−02

cg18336854

TUSC3

− 0.18

[− 0.24, − 0.11]

1.79E−06

4.58E−02

cg24298878

ILF3

− 1.22

[− 1.67, − 0.78]

1.98E−06

4.76E−02