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Table 3 PFASs—significant adjusted differences (BACON-corrected FDR p values < 0.05) in placenta DNA methylation associated with maternal plasma concentration of PFASs (n = 262)

From: Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation

Chemicals CpG Gene logFC [95% CI] BACON-corrected p value BACON-corrected FDR p value
PFDA cg04117229 SPG20 − 0.61 [− 0.78, − 0.45] 6.57E−10 2.69E−04
cg23851558 LOC400940 − 0.16 [− 0.20, − 0.11] 4.83E−08 9.88E−03
cg14355889 MYO18A − 0.07 [− 0.09, − 0.05] 7.36E−08 1.00E−02
cg09441069 FTCD − 0.09 [− 0.12, − 0.06] 2.46E−07 2.30E−02
cg06858599 SNRPG − 0.16 [− 0.22, − 0.11] 2.81E−07 2.30E−02
cg13746315 MCTP2* − 1.05 [− 1.41, − 0.69] 8.39E−07 4.80E−02
cg01352468 ANKRD13B − 0.31 [− 0.41, − 0.20] 9.19E−07 4.80E−02
cg07471462 SLC39A7 − 0.21 [− 0.28, − 0.14] 1.11E−06 4.80E−02
cg23317906 TMX1 − 0.15 [− 0.20, − 0.10] 1.20E−06 4.80E−02
cg18844176 MTHFD1 − 0.33 [− 0.45, − 0.22] 1.21E−06 4.80E−02
cg08912652 SNX19 − 0.33 [− 0.44, − 0.21] 1.41E−06 4.80E−02
cg10391212 CORIN 0.06 [0.04, 0.08] 1.41E−06 4.80E−02
cg13006259 MYL6B − 0.63 [− 0.85, − 0.41] 1.64E−06 4.80E−02
cg07169834 RDM1 0.11 [0.07, 0.15] 1.55E−06 4.80E−02
PFHxS cg21058927 CISD2 − 0.54 [− 0.71, − 0.37] 1.06E−07 4.12E−02
cg11428546 AFF3 − 0.04 [− 0.05, − 0.03] 2.39E−07 4.12E−02
cg10530492 NOL7 − 0.12 [− 0.16, − 0.08] 3.02E−07 4.12E−02
PFNA cg26808417 ARL8A − 0.10 [− 0.13, − 0.07] 6.00E−08 2.45E−02
cg21502999 ELK3 0.31 [0.21, 0.41] 2.40E−07 4.91E−02
PFOS cg17921248 PRKCA 0.06 [0.05, 0.08] 1.43E−08 5.84E−03
cg11891579 EBF1 0.16 [0.11, 0.21] 4.53E−08 9.27E−03
cg01954404 SERPINA1* − 0.10 [− 0.14, − 0.07] 7.22E−08 9.85E−03
PFUnDA cg13996963 TUSC3 0.39 [0.27, 0.51] 8.83E−09 3.61E−03
cg12599971 GRAMD3* − 0.42 [− 0.55, − 0.29] 4.49E−08 9.18E−03
cg15719126 MAPK8IP1 − 0.22 [− 0.29, − 0.15] 8.72E−08 1.10E−02
cg13705616 SHANK2 0.18 [0.12, 0.24] 1.07E−07 1.10E−02
cg12089439 TUSC3 0.40 [0.27, 0.53] 1.92E−07 1.37E−02
cg18145877 TUSC3 0.63 [0.42, 0.84] 2.01E−07 1.37E−02
cg08912652 SNX19 − 0.41 [− 0.55, − 0.27] 4.91E−07 2.87E−02
cg03223126 CUX2 − 0.34 [− 0.46, − 0.22] 7.32E−07 3.34E−02
cg16347018 ATP5E − 1.10 [− 1.49, − 0.72] 7.35E−07 3.34E−02
cg14067524 MYO16 − 0.29 [− 0.39, − 0.18] 1.13E−06 4.38E−02
cg10058241 DOC2B 0.17 [0.11, 0.23] 1.32E−06 4.38E−02
cg09442654 FAM150A 0.55 [0.35, 0.75] 1.40E−06 4.38E−02
cg07471462 SLC39A7 − 0.24 [− 0.33, − 0.15] 1.50E−06 4.38E−02
cg10550693 SYVN1 0.07 [0.04, 0.09] 1.43E−06 4.38E−02
cg24722365 KIF1B − 0.14 [− 0.19, − 0.09] 1.61E−06 4.38E−02
cg18336854 TUSC3 − 0.18 [− 0.24, − 0.11] 1.79E−06 4.58E−02
cg24298878 ILF3 − 1.22 [− 1.67, − 0.78] 1.98E−06 4.76E−02
  1. Adjusted for maternal self-reported race/ethnicity, maternal age in years, fetal sex, maternal pre-pregnancy BMI, cotinine level, methylation sample plate, first three methylation principal component (PCs), the first 10 genotype PCs and Surrogate Variable Analysis (SVA).
  2. logFC logarithm of fold change, FDR false discovery rate
  3. *Annotation from the nearest gene
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Clinical Epigenetics

ISSN: 1868-7083

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