Table 2 OCPs and PCBs—significant adjusted difference (BACON-corrected FDR p values < 0.05) in placenta DNA methylation associated with maternal plasma concentration of POPs (n = 260)

OCPs

HCB

cg27066638

GMIP

− 7.98

[− 10.47, − 5.48]

6.70E−08

2.74E−02

cg11792277

C6orf217

1.27

[0.87, 1.67]

1.69E−07

3.46E−02

Trans-nonachlor

cg27641830

RBM39

− 5.52

[− 6. 18, − 4.24]

9.07E−12

3.71E−06

cg04689409

THNSL1

− 2.76

[− 3.47, − 2.05]

8.13E−10

1.66E−04

cg19851715

HIST1H2BI

0.60

[0.44, 0.77]

7.14E−09

9.73E−04

cg00718518

SH3PXD2B

− 0.26

[− 0.34, − 0.18]

3.23E−07

3.04E−02

cg19358877

ZNF471

− 2.47

[− 3.52, − 1.69]

4.52E−07

3.04E−02

cg13406593

QRFP*

− 0.29

[− 0.39, − 0.20]

5.14E−07

3.04E−02

cg17462356

FASN

− 2.76

[− 3.64, − 1.89]

5.75E−07

3.04E−02

cg23330710

PIGT

− 1.37

[− 1.81, − 0.94]

5.95E−07

3.04E−02

cg07814876

GGPS1;ARID4B

− 2.18

[− 2.88, − 1.49]

6.73E−07

3.06E−02

cg04568710

ALG10B

− 0.95

[− 1.26, − 0.64]

1.07E−06

4.37E−02

p,p′-DDE

cg24596729

LMX1A*

0.13

[0.10, 0.16]

1.27E−10

5.20E−05

cg13910813

AKNA

− 0.26

[− 0.33, − 0.19]

7.74E−09

1.58E−03

PCBs

PCB 138/158

cg06219267

FBXO24

− 0.63

[− 0.81, − 0.46]

2.95E−09

1.21E−03

cg02537221

NHEJ1

− 0.68

[− 0.88, − 0.49]

8.82E−09

1.80E−03

cg01110147

PSMA3

0.23

[0.16, 0.29]

9.17E−08

1.25E−02

PCB 153

cg06219267

FBXO24

− 0.63

[− 0.81, − 0.44]

7.04E−08

2.88E−02

PCB 180

cg18663897

NDUFA10

− 0.56

[− 0.70, − 0.42]

2.02E−10

8.27E−05

cg19179910

MUC21

− 0.45

[− 0.57, − 0.32]

5.25E−08

1.07E−02

cg11562147

C6orf222

0.11

[0.08, 0.14]

1.36E−07

1.39E−02

cg26184687

MKNK2

− 0.18

[− 0.23, − 0.12]

1.11E−07

1.39E−02

cg17874528

KLHL25

− 0.23

[− 0.30, − 0.16]

3.21E−07

2.63E−02