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Table 2 OCPs and PCBs—significant adjusted difference (BACON-corrected FDR p values < 0.05) in placenta DNA methylation associated with maternal plasma concentration of POPs (n = 260)

From: Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation

Class Chemicals CpG Gene logFC [95% CI] BACON-corrected p value BACON-corrected FDR p value
OCPs HCB cg27066638 GMIP − 7.98 [− 10.47, − 5.48] 6.70E−08 2.74E−02
cg11792277 C6orf217 1.27 [0.87, 1.67] 1.69E−07 3.46E−02
Trans-nonachlor cg27641830 RBM39 − 5.52 [− 6. 18, − 4.24] 9.07E−12 3.71E−06
cg04689409 THNSL1 − 2.76 [− 3.47, − 2.05] 8.13E−10 1.66E−04
cg19851715 HIST1H2BI 0.60 [0.44, 0.77] 7.14E−09 9.73E−04
cg00718518 SH3PXD2B − 0.26 [− 0.34, − 0.18] 3.23E−07 3.04E−02
cg19358877 ZNF471 − 2.47 [− 3.52, − 1.69] 4.52E−07 3.04E−02
cg13406593 QRFP* − 0.29 [− 0.39, − 0.20] 5.14E−07 3.04E−02
cg17462356 FASN − 2.76 [− 3.64, − 1.89] 5.75E−07 3.04E−02
cg23330710 PIGT − 1.37 [− 1.81, − 0.94] 5.95E−07 3.04E−02
cg07814876 GGPS1;ARID4B − 2.18 [− 2.88, − 1.49] 6.73E−07 3.06E−02
cg04568710 ALG10B − 0.95 [− 1.26, − 0.64] 1.07E−06 4.37E−02
p,p′-DDE cg24596729 LMX1A* 0.13 [0.10, 0.16] 1.27E−10 5.20E−05
cg13910813 AKNA − 0.26 [− 0.33, − 0.19] 7.74E−09 1.58E−03
PCBs PCB 138/158 cg06219267 FBXO24 − 0.63 [− 0.81, − 0.46] 2.95E−09 1.21E−03
cg02537221 NHEJ1 − 0.68 [− 0.88, − 0.49] 8.82E−09 1.80E−03
cg01110147 PSMA3 0.23 [0.16, 0.29] 9.17E−08 1.25E−02
PCB 153 cg06219267 FBXO24 − 0.63 [− 0.81, − 0.44] 7.04E−08 2.88E−02
PCB 180 cg18663897 NDUFA10 − 0.56 [− 0.70, − 0.42] 2.02E−10 8.27E−05
cg19179910 MUC21 − 0.45 [− 0.57, − 0.32] 5.25E−08 1.07E−02
cg11562147 C6orf222 0.11 [0.08, 0.14] 1.36E−07 1.39E−02
cg26184687 MKNK2 − 0.18 [− 0.23, − 0.12] 1.11E−07 1.39E−02
cg17874528 KLHL25 − 0.23 [− 0.30, − 0.16] 3.21E−07 2.63E−02
  1. Adjusted for maternal self-reported race/ethnicity, maternal age in years, fetal sex, maternal pre-pregnancy BMI, total lipid, cotinine level, methylation sample plate, first three methylation principal component (PCs), the first 10 genotype PCs, and surrogate variable analysis (SVA)
  2. logFC logarithm of fold change, FDR false discovery rate
  3. * Annotation from the nearest gene
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Clinical Epigenetics

ISSN: 1868-7083

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