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Table 2 Results of MANCOVA of OXTR DNA methylation between patients with OCD and healthy controls for men and women

From: Reduced DNA methylation of the oxytocin receptor gene is associated with obsessive-compulsive disorder

 

Men

Women

OCDa (n = 112)

HCa (n = 56)

 

OCDa (n = 39)

HCa (n = 52)

 

F

pb

ηp2c

F

pb

ηp2c

  

Statistics: Wilks λ = 0.822, F(4, 161) = 8.693, p < 0.001

Statistics: Wilks λ = 0.736, F(4, 84) = 7.525, p < 0.001

OXTR1 (exon2)

CpG1 (-959)

40.94 ± 5.17

45.67 ± 4.88

20.012

< 0.001

0.109†

42.94 ± 5.13

47.70 ± 3.89

21.784

< 0.001

0.200‡

 

CpG2 (-934)

46.33 ± 5.21

50.44 ± 4.52

22.873

< 0.001

0.122†

49.11 ± 5.75

52.54 ± 3.14

10.631

0.002

0.109†

 

CpG3 (-924)

58.08 ± 5.25

59.62 ± 3.82

1.835

0.177

0.011

60.36 ± 5.86

60.74 ± 3.75

0.032

0.858

< 0.001

OXTR2 (exon3)

Mean value of CpG1-8

13.81 ± 5.46

13.34 ± 5.66

0.233

0.630

0.001

14.80 ± 4.49

14.14 ± 4.57

0.020

0.888

< 0.001

  1. MANCOVA demonstrated significant between-group differences after controlling for age and education
  2. MANCOVA multivariate analysis of covariance, OCD obsessive-compulsive disorder, HC healthy control
  3. aMean ± standard deviation of raw data
  4. bStatistical significance was set at p < 0.0125 after Bonferroni correction for the 4 CpG sites
  5. cEffect size was calculated using partial eta squared and interpreted according to the rule of Miles and Shevlin (2001)
  6. †Medium effect (> 0.06)
  7. ‡Large effect (> 0.14)
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Clinical Epigenetics

ISSN: 1868-7083

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