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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer

Fig. 6

Validation of intron hypermethylation in the candidate genes, CDH5 and LRIG1. a Comparison of overall methylation states in the surrounding regions of the intronic PAX5 motif in CDH5 and LRIG1 genes. Methylation was measured by the ratio of cytosine on each CG site. Red lines between CMT and adjacent normal indicate hypermethylation, while blue lines indicate hypomethylation. N, adjacent normal; C, CMT. Statistical p value was calculated by paired t test. b Differential methylation is depicted in three separated CMT subtypes

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