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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer

Fig. 4

Intron DMRs may associate with cancer-related genes. a The DMGs are catagorized into 7 groups based on the combination of the DMR’s genic loci. I, intron only; EI, exon+intron; P, promoter only; E, exon only; PI, promoter+intron; PEI, promoter+exon+intron; and PE, promoter+exon. Red color indicates DMGs containing intron DMRs. b Venn diagram differentially presents intron DMRs (red) in 7 groups. c KEGG pathway analysis with intron DMRs shows cancer-related pathways are highly enriched in I and EI group. Both x-axis and gradient color indicates significance (− log10 (p value)), and the circle indicates the count of DMGs

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