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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer

Fig. 3

Functional association of DMGs. a Hierarchical clustering of CMT-DMGs separates 11 adjacent normal (light blue) and 11 CMT (dark blue) independent of subtypes (simple, yellow; ductal, green; and complex, blue). Methylation levels were z-scored and are indicated by blue (hypo) and red (hyper) scale. b OncoScore of 224 CMT-DMGs were measured and those with a score greater than 50 are depicted. Dark blue indicates hypermethylated DMGs and downregulated in RNA-seq data and light blue indicates hypomethylated DMGs and upregulated in RNA-seq data. c Box plot shows the expression level of the top 4 orthologous genes from the TCGA database ranked by OncoScore in normal (light blue) and human invasive breast cancer (dark blue). d CMT-DMGs were clustered into the library of Disease Perturbations from GEO (down). The top 7 terms are composed of breast cancer related terms. h, human; r, rat; m, mouse; (1) breast cancer C0006142 rat GSE1872; (2) breast cancer DOID-1612 human GSE26910; (3) sporadic breast cancer DOID-8029 human GSE3744; (4) colorectal adenocarcinoma DOID-0050861 human GSE24514; (5) tendonopathy 971 human GSE26051; (6) neurological pain disorder C0423704 rat GSE15041; and (7) ductal carcinoma in situ DOID-0060074 human GSE21422. See the Table S6 to show a list of terms and p values. e Hierarchical clustering of subtype-DMGs. f GO enrichment analysis in biological process (left) and cellular component (right). Duct, ductal; Comp, complex; and Simp, simple subtype. Length of bar represents − log 10 (p value)

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