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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer

Fig. 2

Identification of differentially methylated regions (DMRs) among the three CMT subtypes and between CMT and adjacent normal. a LMM separated CMT-DMRs (orange) and subtype-DMRs (blue green). Gray indicates none. b PCA analysis using CMT-DMRs and subtype-DMRs. CMT-DMRs successfully divides adjacent normal (green) and CMT (purple) and also subtype-DMRs into simple (orange), ductal (blue), and complex (red) types. c Genomic distribution of CMT-DMRs (up) and subtype-DMRs (down). Distribution between genic and intergenic regions (left), CGI and non-CGI (middle), and repeat and non-repeat (right). d Hyper- and hypomethylation profiles in CMT-DMRs and subtype-DMRs. Colored region (orange and blue green): hypermethylation, gray: hypomethylation

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Clinical Epigenetics

ISSN: 1868-7083

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