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Table 2 The odds ratio (OR) and its 95% confidence interval (95% CI) of positive ratios of different screening methods in various histological types

From: DNA methylation for cervical cancer screening: a training set in China

 OR (95% CI) of positive methylationapOR (95% CI) of positive hrHPVapOR (95% CI) of positive methylation and hrHPVap
Inflammation (n = 78)ReferenceReferenceReference
CIN1 (n = 40)0.461 (0.093–2.279)0.3421.269 (0.519–3.106)0.6020.374 (0.042–3.318)0.377
CIN2 (n = 29)2.283 (0.717–7.271)0.1631.158 (0.432–3.106)0.7713.042 (0.810–11.416)0.099
CIN3 (n = 91)21.875 (9.244–51.764)< 0.0014.421 (1.763–11.804)0.00229.687 (10.856–81.178)< 0.001
SCC (n = 52)446.250 (54.106–3680.553)< 0.0016.018 (1.692–21.396)0.006238.467 (54.479–1043.821)< 0.001
Endocervical ADC (n = 11)87.500 (9.872–775.520)< 0.0011.658 (0.331–8.309)0.53965.700 (11.079–389.600)< 0.001
Inflammation or CIN1 (n = 118)ReferenceReferenceReference
CIN2+ (n = 183)27.953 (13.552–57.656)< 0.0012.943 (1.567–5.527)0.00139.232 (16.308–94.381)< 0.001
  1. ADC adenocarcinoma, CIN cervical intraepithelial neoplasia, CIN2+ lesions of CIN2 or more severe, HGSC high grade serous carcinoma, hrHPV high risk human papillomavirus, N/A not available, SSC squamous cell carcinoma
  2. aPositive methylation status indicates calculated values of at least one of the targeted genes below the cutoff values