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Table 2 The odds ratio (OR) and its 95% confidence interval (95% CI) of positive ratios of different screening methods in various histological types

From: DNA methylation for cervical cancer screening: a training set in China

 

OR (95% CI) of positive methylationa

p

OR (95% CI) of positive hrHPVa

p

OR (95% CI) of positive methylation and hrHPVa

p

Inflammation (n = 78)

Reference

–

Reference

–

Reference

–

CIN1 (n = 40)

0.461 (0.093–2.279)

0.342

1.269 (0.519–3.106)

0.602

0.374 (0.042–3.318)

0.377

CIN2 (n = 29)

2.283 (0.717–7.271)

0.163

1.158 (0.432–3.106)

0.771

3.042 (0.810–11.416)

0.099

CIN3 (n = 91)

21.875 (9.244–51.764)

< 0.001

4.421 (1.763–11.804)

0.002

29.687 (10.856–81.178)

< 0.001

SCC (n = 52)

446.250 (54.106–3680.553)

< 0.001

6.018 (1.692–21.396)

0.006

238.467 (54.479–1043.821)

< 0.001

Endocervical ADC (n = 11)

87.500 (9.872–775.520)

< 0.001

1.658 (0.331–8.309)

0.539

65.700 (11.079–389.600)

< 0.001

Inflammation or CIN1 (n = 118)

Reference

–

Reference

–

Reference

–

CIN2+ (n = 183)

27.953 (13.552–57.656)

< 0.001

2.943 (1.567–5.527)

0.001

39.232 (16.308–94.381)

< 0.001

  1. ADC adenocarcinoma, CIN cervical intraepithelial neoplasia, CIN2+ lesions of CIN2 or more severe, HGSC high grade serous carcinoma, hrHPV high risk human papillomavirus, N/A not available, SSC squamous cell carcinoma
  2. aPositive methylation status indicates calculated values of at least one of the targeted genes below the cutoff values