meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes

Table 5 Significant SNP-ncRNA pairs after the Bonferroni multiple-testing adjustment

SNP	RefGene	Position (hg19)	ncRNA	Host gene	Bonferroni-adj. p value	% ncRNA mRNA levels difference
rs7117514	SHANK2	11:70544937	hsa-miR-3664-5p	SHANK2	0.015	5.2
rs72710803	AL122019	1:177428018	hsa-miR-488-5p	ASTN1	0.026	10
rs301799	RERE	1:8489302	hsa-miR-6728-3p	ENO1	0.032	− 8.9
rs7659414	–	4:177350956	ENSG00000201516	WDR17	0.037	− 3.9

Linear models with ncRNA expression as outcome and SNP, age, and sex as predictors. The difference in mRNA levels is shown between major allele carriers and heterozygous and homozygous for minor allele
SNP single nucleotide polymorphism, ncRNA non-coding RNA

ISSN: 1868-7083