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Table 1 Characteristics of the adolescents from the discovery cohort

From: meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes

  Low-risk (n = 160) High-risk (n = 56) p value**
Male: Female 47 (19.4):113 (80.6) 6 (13.1):50 (86.9) 0.0089
Age (years) 15.4 ± 0.63 15.6 ± 0.65 0.15
Body mass index (kg/m2) 21.61 ± 3.02 22.83 ± 4.33 0.054
DAWBA level bands*    
 General band 70 (19.4) 56 (100) 6.03e-14
 Panic disorder 9 (5.6) 5 (8.9) 0.00041
 Posttraumatic disorder 14 (2.5) 9 (16) 5.44e-6
 Separation anxiety disorder 5 (3.1) 6 (10.7) 2.05e-5
 Generalized anxiety disorder 30 (18.7) 23 (41.1) 2.11e-7
 Social phobia 17 (10.6) 14 (25) 0.016
 Obsessive-compulsive disorder 9 (5.6) 6 (10.7) 0.028
 Conduct disorder 10 (6.2) 9 (16.1) 7.89e-6
 Specific phobia 9 (5.6) 7 (12.5) 0.0072
  1. Variables are shown as mean ± standard deviation or number (percentage)
  2. *All listed DAWBA bands refer to individuals at high-risk (defined by DAWBA bands = 3, 4, or 5) of, e.g., general band, depression, and panic disorder
  3. **Two-tailed Student’s t test for continuous variables and chi-square test for categorical variables (likelihood ratio). Significant p values are written in bold and italics
  4. Individuals with depression DAWBA band risk scores <15% were considered at low-risk for depression; individuals with depression DAWBA level bands 3 (≈ 15%), 4 (≈ 50%), or 5 (> 70%) were considered at high-risk for depression
  5. DAWBA Development and Well-Being Assessment