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Table 1 Characteristics of the adolescents from the discovery cohort

From: meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes

 

Low-risk (n = 160)

High-risk (n = 56)

p value**

Male: Female

47 (19.4):113 (80.6)

6 (13.1):50 (86.9)

0.0089

Age (years)

15.4 ± 0.63

15.6 ± 0.65

0.15

Body mass index (kg/m2)

21.61 ± 3.02

22.83 ± 4.33

0.054

DAWBA level bands*

   

 General band

70 (19.4)

56 (100)

6.03e-14

 Panic disorder

9 (5.6)

5 (8.9)

0.00041

 Posttraumatic disorder

14 (2.5)

9 (16)

5.44e-6

 Separation anxiety disorder

5 (3.1)

6 (10.7)

2.05e-5

 Generalized anxiety disorder

30 (18.7)

23 (41.1)

2.11e-7

 Social phobia

17 (10.6)

14 (25)

0.016

 Obsessive-compulsive disorder

9 (5.6)

6 (10.7)

0.028

 Conduct disorder

10 (6.2)

9 (16.1)

7.89e-6

 Specific phobia

9 (5.6)

7 (12.5)

0.0072

  1. Variables are shown as mean ± standard deviation or number (percentage)
  2. *All listed DAWBA bands refer to individuals at high-risk (defined by DAWBA bands = 3, 4, or 5) of, e.g., general band, depression, and panic disorder
  3. **Two-tailed Student’s t test for continuous variables and chi-square test for categorical variables (likelihood ratio). Significant p values are written in bold and italics
  4. Individuals with depression DAWBA band risk scores <15% were considered at low-risk for depression; individuals with depression DAWBA level bands 3 (≈ 15%), 4 (≈ 50%), or 5 (> 70%) were considered at high-risk for depression
  5. DAWBA Development and Well-Being Assessment