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Fig. 3 | Clinical Epigenetics

Fig. 3

From: meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes

Fig. 3

Genomic context of the CpG site associated with the depressive phenotype and genetic variant rs1933802. Genomic positions of RefSeq genes are displayed in the top part and indicated by arrows. The position of the significant CpG site is highlighted by black lines. Since analyses were performed based on data obtained in blood, chromatin marks overlapping in brain and blood cells were investigated. Chromatin states of 8 tissues downloaded from the 37/hg19 WashU Epigenome Browser are illustrated. Each functional role of a segment is indicated by a particular color. BrainAC, brain anterior caudate; BrainCG, brain cingulate gyrus; BrainHIPPO, brain hippocampus; BrainITL, brain inferior temporal lobe; BrainDPC, brain dorsolateral prefrontal cortex; BrainSN, brain substantia nigra; BrainAG, brain angular gyrus; PBMC, peripheral blood mononuclear primary cells

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