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Table 3 PD-L2 methylation and mRNA expression in melanoma cell lines

From: Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma

 Methylation [%] or mRNA expression (mRNA: N = 19, methylation: N = 37)Correlation with mRNA expression (N = 19)
AnalyteMean (95% confidence interval)Spearman’s ρP value
PD-L2 mRNA6.9 (6.4–7.4)NANA
cg1444066458.1 (49.7–66.5)− 0.3790.11
cg0721125926.4 (19.3–33.6)− 0.5040.028
cg1435195268.5 (61.1–75.8)0.5260.021
cg1413306453.0 (44.9–61.2)− 0.0160.96
cg1437499486.2 (80.9–91.5)0.3330.16
  1. N = 37 melanoma cell lines (N = 4 primary melanomas, N = 17 lymph node metastases, N = 16 brain metastases) obtained by Marzese et al. [32]. PD-L2 methylation was determined at five different CpG sites, each gene targeted by HumanMethylation450 BeadChip beads (Fig. 1). Significant features are shown in boldface.