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Table 2 Correlations of PD-L2 methylation and mRNA expression with IFN-γ signature

From: Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma

 IFNGSTAT1STAT2STAT3JAK2IRF9
AnalyteSpearman’s ρP valueSpearman’s ρP valueSpearman’s ρP valueSpearman’s ρP valueSpearman’s ρP valueSpearman’s ρP value
PD-L2 mRNA0.81< 0.0010.76< 0.0010.32< 0.0010.36< 0.0010.62< 0.0010.51< 0.001
cg144406640.160.0010.16< 0.0010.21< 0.0010.040.450.140.0020.120.008
cg07211259− 0.46< 0.001− 0.46< 0.001− 0.34< 0.001− 0.130.004− 0.21< 0.001− 0.45< 0.001
cg143519520.130.0040.19< 0.0010.140.0020.080.0860.23< 0.0010.18< 0.001
cg14133064− 0.30< 0.001− 0.150.0020.030.57− 0.040.35− 0.040.42− 0.130.004
cg143749940.24< 0.0010.21< 0.0010.060.230.120.0090.27< 0.0010.120.007
  1. Correlations of PD-L2 methylation and mRNA expression with mRNA expression of IFNG and IFN-γ–regulated genes (STAT1, STAT2, STAT3, JAK2, and IRF9). DNA methylation was determined at five different CpG sites, each gene targeted by HumanMethylation450 BeadChip beads (Fig. 1). Significant features are shown in boldface. Data were procurable from N = 468 tumor samples