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Table 1 The SNPs selected for the current analyses, along with the names of the nearest genes (if any), and the measures of association (relative risks (RR), 95% confidence intervals (CI), and p values; taken from Tables 1–3 in Ref. [24])

From: Gene–methylation interactions: discovering region-wise DNA methylation levels that modify SNP-associated disease risk

SNP Locus Minor allelea MAFa RR 95% CI p value Cleft subtypeb
rs12543318 8q21.3 c 0.31 1.51 1.31–1.75 4.46e −8 CLO
rs987525 8q24 a 0.19 1.85 1.63–2.10 1.47e −19 CLP
rs560426 ABCA4 g 0.44 1.24 1.10–1.41 3.91e −4 CLP
rs3758249 FOXE1 t 0.36 0.78 0.69–0.88 8.18e −5 CLP
rs642961 IRF6 a 0.23 1.60 1.36–1.87 1.41e −8 CLO
rs7078160 KIAA1598 a 0.17 1.33 1.15–1.53 1.04e −4 CLP
rs13041247 MAFB c 0.41 0.67 0.59–0.76 2.32e −9 CLP
rs227731 NOG1 g 0.47 0.74 0.64–0.85 3.8e −5 CPO
rs742071 PAX7 t 0.38 1.52 1.31–1.75 3.74e −8 CLO
rs8001641 SPRY2 g 0.54 0.79 0.70–0.90 2.05e −4 CLP
rs7590268 THADA g 0.25 1.27 1.12–1.46 3.96e −4 CLP
rs1873147 TPM1 g 0.27 1.31 1.13–1.53 5.82e −4 CLO
  1. aThe minor allele and its frequency (MAF) for the Norwegian population were taken from Table 1 in the Appendix of Ref. [24]
  2. bThe cleft subtype (CLO, CPO, or CLP) for which the association was the strongest