Fig. 8

PoO ×Me interaction between a parent-of-origin effect of rs227731 in NOG1 and the methylation level of the CpGs within a promoter region nearby. The x-axis groups the results into the unstratified dataset “all” and the results for each stratum: “1” denoting low methylation level, “2” — medium, and “3” — high methylation level. The minor and reference alleles are given for each group, along with their frequencies. The y-axis shows the relative risk on a log scale, with “cm_cf” denoting the parent-of-origin effect when only one minor allele is inherited (single dose) and “cdd” denoting the parent-of-origin effect when two such alleles are inherited (double dose)