Fig. 4

G ×Me effect between rs12543318 at locus 8q21.3 and the methylation level of the CpG from the promoter region nearby. The x-axis groups the results into the unstratified dataset “all” and the results for each stratum: “1” denoting low methylation level, “2”—medium, and “3”—high methylation level. The minor and reference alleles are given for each group, along with their frequencies. The y-axis shows the relative risk on a log scale, with “c” denoting the child effect when only one minor allele is inherited (single dose) and “cdd” denoting the child effect when two such alleles are inherited (double dose)