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Fig. 5 | Clinical Epigenetics

Fig. 5

From: G9a regulates tumorigenicity and stemness through genome-wide DNA methylation reprogramming in non-small cell lung cancer

Fig. 5

G9A inhibitor UNC0642 suppressed tumor growth of mouse xenografts (from LCSC2 and LCSC4). a UNC0642 treatment 10 mg/ml) inhibited LCSC2 xenografts growth as shown in growth curve (left panel) and as resected tumors (right panel). b Tumor weight in mice treated with control (vehicle) and 10 mg/ml UNC0642 shows a level of suppression of tumor growth in mice (P = NS; not significant). c UNC0642 treatment (10 mg/ml) inhibited LCSC2 xenografts growth as shown in growth curve (left panel) and as resected (right panel). d Tumor weight in mice treated with control (vehicle) and UNC0642 (10 mg/ml) shows tumor growth in treated mice is statistically significant (*P = 0.05). e IHC staining of the tumors from the mouse xenografts shows reduced G9A expression (for validation of its knockdown) and H3K9Me2 level and increased expression of FOXP1 and SP5 both in LCSC2 and LCSC4 (× 20 magnification). (For t test: *P < 0.05, **P < .01, and ***P < 0.001)

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