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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer

Fig. 3

Inverse correlation between DNA methylation and mRNA expression of the AATK gene in different cohorts. a Dot-plot illustration of the relative mRNA expression levels of AATK-variant 1 or variant 2 in normal and tumor tissues of PDA patients. b A significant inverse correlation between DNA methylation and mRNA expression was found in PDA patients. c DNA methylation level is indicated on the Y-axis and the X-axis represents the adjacent normal and tumor samples from two cohorts with different CpG probes. P values were calculated by a two-tailed paired t test and are shown as indicated. d Inverse correlation between DNA methylation and mRNA expression was found in the TCGA dataset

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