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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Methylome profiling of young adults with depression supports a link with immune response and psoriasis

Fig. 1

Methylation gains at immune response genes in stratified cases. a Principal component analysis (PCA) for all methylated sites of the 32 samples from subjects showing comorbid depression, self-harm and suicidal attempt compared to healthy controls. This indicated clear separation by gender, but also between cases (orange) and controls (green) for females. b Scatterplot of differential methylation, with the top 1000 probes in red. c Gene ontology analysis of the top differentially methylated gene bodies shows significant enrichment for immune system response terms. d Reanalysis of array data using an in-house Galaxy workflow. Differentially methylated probes whose coordinates matched genes from the top two ranks in c (relating to immune system response) were identified. Median methylation levels were assessed and again showed a significant difference between cases and controls (**p < 0.01)

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