Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer

Table 2 Multivariate linear regression analysis as predictor of response of neoadjuvant treatment using SFRP2 methylation promoter

Variables	< 30th percentile of vitamin D; R² = 0.23; R^2# = 0.01; p = 0.412		> 30th percentile of vitamin D; R² = 0.32; R^2# = 0.24; p = 0.009*
	β (SE)	95% CI	β (SE)	95% CI
Gender	2.87 (11.28)	(− 21.32 to 27.07)	11.87 (7.55)	(− 3.48 to 27.21)
Age (years)	0.09 (0.66)	(− 1.31 to 1.50)	− 0.63 (0.37)	(− 1.40 to 0.12)
BMI	0.82 (1.46)	(− 2.31 to 3.95)	− 0.70 (0.85)	(− 2.44 to 1.04)
Neoadjuvant treatment	− 9.43 (4.68)	(− 19.48 to 0.61)	− 8.15 (2.58)**	(− 13.40 to (− 2.90))

The multivariate linear regression analyses were conducted using SFRP2 promoter methylation in tumor area as dependent variable, and age, gender, BMI, and treatment after surgery in tumor area as independent parameters, according to the 30th percentile of vitamin D (# adjusted). Asterisk indicates significant correlation (*p < 0.05, **p < 0.01)
SFRP2 secreted frizzled-related protein type 2

ISSN: 1868-7083