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Table 3 Supplementary information retrieved by in silico analysis for methylation sites without annotated gene and chromosome position

From: Epigenome-wide association study in healthy individuals identifies significant associations with DNA methylation and PBMC extract VEGF-A concentration

CpG site (strand)

 

cg16333561 (−)

cg15014826 (+)

cg08759276 (−)

cg05275012 (−)

cg10517202 (−)

cg13332754 (−)

Chromosome

 

7p21.2

19p13.12

16q24.1

3p22.1

3q26.32

18q22.3

Nearest genomic feature (product/strand)

Upstream

AC011287.1 (novel lincRNA/+)

ZSWIM4 (protein coding/+)

AC009108.4 (unknown/+)

AC122683.1 (lincRNA/−)

LINC00578 (lincRNA/+)

TSHZ1 (protein coding/+)

Downstream

AC005019.2 (novel lincRNA/−)

AC020916.1 (lincRNA/−)

AC009108.2 (lincRNA/−)

HMGN2P24 (pseudogene/−)

RN7SKP52 (misc RNA/−)

TSHZ1 (protein coding/+)

Location

 

7:13803079–13803128

19:13833585–13833634

16:86610656–86610705

3:40619738–40619787

3:177469455–177469504

18:75290150–75290199

Regulatory features (T cells, natural killer cells or B cells)

 

1 enhancer and 2 CTCF binding sites

8 promoters

4 promoters and 1 CTCF binding site

1 promoter, 1 enhancer and 3 CTCF binding sites

1 promoter; 1 CTCF and 1 enhancer

1 promoter; 2 enhancers and 1 CTCF binding site

Nearest coding gene (strand)

Upstream

ARL4A (+)

ZSWIM4 (+)

FOXL1 (+)

ZNF621 (+)

TBL1XR1 ()

TSHZ1, ZADH2 (+)

Downstream

ETV1 ()

NANOS3 (+)

C16orf95 ()

CTNNB1 (+)

KCNMB2 (+)

SMIM21 ()