Table 2 Novel associations between VEGFA levels and DNA methylation in a subset of the STANISLAS Family Study, after Holm-Bonferroni correction (P < 1.6 × 10−07). Data retrieved from the CpGassoc annotation file
CpG Site | Chromosome | Gene | Location | Mean beta values | Effect size | P value |
|---|---|---|---|---|---|---|
cg05739757 | 2q11.2 | RPL31 | TSS200 | 0.07 | 0.00176 | 5.64 × 10−15 |
cg23333878 | 9p24.2 | GLIS3 | 5′UTR; 1stExon | 0.08 | 0.00270 | 3.86 × 10−14 |
cg21838233 | 20q11.21 | TPX2 | 1stExon; 5′UTR | 0.04 | 0.00191 | 4.01 × 10−12 |
cg18815539 | 4p15.2 | SEPSECS | 1stExon; 5′UTR | 0.04 | − 0.00197 | 1.70 × 10−12 |
cg21968169 | 12q24.31 | LOC338799, SETD1B | TSS1500 | 0.09 | − 0.00189 | 1.11 × 10−12 |
cg16333561 | 7q11.23 | ND | ND | 0.90 | − 0.00130 | 7.02 × 10−11 |
cg20547575 | 7q11.22 | AUTS2 | Body | 0.03 | − 0.00349 | 1.52 × 10−10 |
cg15014826 | 19p13.12 | ND | ND | 0.03 | − 0.00157 | 1.12 × 10−10 |
cg00117600 | 15q21.3 | PIGB | 5′UTR; 1stExon | 0.04 | 0.00118 | 8.84 × 10−09 |
cg08759276 | 16q24.1 | ND | ND | 0.78 | − 0.00153 | 3.31 × 10−09 |
cg05275012 | 3p22.1 | ND | ND | 0.94 | 0.00176 | 8.81 × 10−08 |
cg10517202 | 3q26.32 | ND | ND | 0.88 | − 0.00103 | 8.74 × 10−08 |
cg09614565 | 3p14.3 | IL17RD | TSS200 | 0.02 | − 0.00283 | 5.69 × 10−08 |
cg13689591 | 3q21.1–q21.2 | KALRN | Body | 0.88 | 0.00199 | 2.58 × 10−08 |
cg06934988 | 17p13.1 | USP43 | TSS200 | 0.02 | − 0.00188 | 1.96 × 10−08 |
cg06785213 | 19q13.4 | HAS1 | TSS200 | 0.20 | 0.00087 | 1.06 × 10−08 |
cg13332754 | 18q22.3 | ND | ND | 0.95 | 0.00164 | 1.39 × 10−07 |
cg03551607 | 13q14.2 | ESD | 5′UTR | 0.04 | 0.00115 | 1.34 × 10−07 |
cg24364967 | 2p16.1 | CLHC1 | 5′UTR | 0.12 | 0.00122 | 1.22 × 10−07 |
cg15057061 | 3q26.33 | SOX2OT | Body | 0.04 | − 0.00151 | 1.08 × 10−07 |