Table 3 Significantly enriched pathways enriched in genes annotated to top 100 CpGs associated with birthweight
Ingenuity canonical pathways | Molecules | p value | FDR p value |
|---|---|---|---|
Assembly of RNA polymerase I complex | POLR1E, POLR1C | 1.0E− 03 | 0.008 |
CTLA4 signaling in cytotoxic T lymphocytes | AP1G1, FGFR2, PTPN22 | 1.1E− 02 | 0.016 |
DNA methylation and transcriptional repression signaling | CHD4, CHD3 | 1.1E− 02 | 0.016 |
Protein kinase A signaling | FLNB, PPP3R1, PTPRE, PTPN22, ANAPC11, PDE9A | 9.0E− 03 | 0.016 |
Pyrimidine deoxyribonucleotides de novo biosynthesis I | RRM2, RRM2B | 5.0E− 03 | 0.016 |
mTOR signaling | FGFR2, PRR5L, ARHGAP8/PRR5-ARHGAP8, PRR5 | 1.5E− 02 | 0.018 |
Virus entry via endocytic pathways | FLNB, AP1G1, FGFR2 | 1.8E− 02 | 0.018 |