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Table 2 Expression of genes in cis-region (± 500 kb) of birthweight-associated CpG sites associated with DNA methylation and their correlation with birthweight

From: DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases

CpG site

Gene

Association between gene expression and DNA methylation

Correlation between gene expression and birthweight

Coeff

SE

p value

FDR p value

Pearson r

p value

cg00768487 (chr1)

SH3BGRL3

− 0.00055

0.000108

2.30E− 06

5.75E− 05

− 0.145

0.21

UBXN11

− 0.00303

0.000647

1.25E− 05

1.56E− 04

− 0.117

0.31

RPS6KA1*

− 0.00126

0.000295

5.53E− 05

4.61E− 04

− 0.127

0.27

CD52*

− 0.0015

0.000407

4.50E− 04

2.81E− 03

− 0.169

0.14

DHDDS*

− 0.00112

0.000378

4.27E− 03

1.78E− 02

− 0.017

0.88

ZNF683

− 0.0395

0.013312

4.06E− 03

1.78E− 02

− 0.056

0.63

cg08973382 (chr2)

HK2*

− 0.00024

6.43E− 05

2.90E− 04

8.42E− 03

− 0.158

0.17

SEMA4F*

− 0.00258

0.000747

9.14E− 04

1.32E− 02

− 0.108

0.35

cg06155341 (chr11)

TMEM151A*

− 0.05519

0.012548

3.65E− 05

1.61E− 03

− 0.136

0.24

CATSPER1*

− 0.00396

0.001153

9.86E− 04

2.17E− 02

− 0.170

0.14

KLC2

0.000382

0.000117

1.62E− 03

2.37E− 02

0.047

0.69

CST6

− 0.00026

8.34E− 05

3.10E− 03

3.41E− 02

− 0.064

0.58

RAB1B

0.00015

5.14E− 05

4.63E− 03

3.62E− 02

0.009

0.93

FOSL1*

− 0.00391

0.001349

4.93E− 03

3.62E− 02

− 0.248

0.03

cg24450112 (chr21)

UBASH3A

0.040597

0.013412

3.41E− 03

4.78E− 02

− 0.209

0.07

  1. *CpG located upstream relative to the promotor (start of gene)