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Table 2 Expression of genes in cis-region (± 500 kb) of birthweight-associated CpG sites associated with DNA methylation and their correlation with birthweight

From: DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases

CpG site Gene Association between gene expression and DNA methylation Correlation between gene expression and birthweight
Coeff SE p value FDR p value Pearson r p value
cg00768487 (chr1) SH3BGRL3 − 0.00055 0.000108 2.30E− 06 5.75E− 05 − 0.145 0.21
UBXN11 − 0.00303 0.000647 1.25E− 05 1.56E− 04 − 0.117 0.31
RPS6KA1* − 0.00126 0.000295 5.53E− 05 4.61E− 04 − 0.127 0.27
CD52* − 0.0015 0.000407 4.50E− 04 2.81E− 03 − 0.169 0.14
DHDDS* − 0.00112 0.000378 4.27E− 03 1.78E− 02 − 0.017 0.88
ZNF683 − 0.0395 0.013312 4.06E− 03 1.78E− 02 − 0.056 0.63
cg08973382 (chr2) HK2* − 0.00024 6.43E− 05 2.90E− 04 8.42E− 03 − 0.158 0.17
SEMA4F* − 0.00258 0.000747 9.14E− 04 1.32E− 02 − 0.108 0.35
cg06155341 (chr11) TMEM151A* − 0.05519 0.012548 3.65E− 05 1.61E− 03 − 0.136 0.24
CATSPER1* − 0.00396 0.001153 9.86E− 04 2.17E− 02 − 0.170 0.14
KLC2 0.000382 0.000117 1.62E− 03 2.37E− 02 0.047 0.69
CST6 − 0.00026 8.34E− 05 3.10E− 03 3.41E− 02 − 0.064 0.58
RAB1B 0.00015 5.14E− 05 4.63E− 03 3.62E− 02 0.009 0.93
FOSL1* − 0.00391 0.001349 4.93E− 03 3.62E− 02 − 0.248 0.03
cg24450112 (chr21) UBASH3A 0.040597 0.013412 3.41E− 03 4.78E− 02 − 0.209 0.07
  1. *CpG located upstream relative to the promotor (start of gene)