Table 4 Individual and joint predictive performance of pack-years, GRS, and MRS for LC risk
Predictor | AUC (95% CI) | NRIa | IDIa | |||
|---|---|---|---|---|---|---|
Apparent | .632+ | % | p value | % | p value | |
All participantsb | ||||||
GRS | 0.587 (0.536–0.638) | 0.586 (0.535–0.637) | ||||
MRS | 0.777 (0.731–0.823) | 0.777 (0.731–0.823) | ||||
GRS + MRS | 0.784 (0.738–0.830) | 0.783 (0.738–0.829) | ||||
Pack-years | 0.782 (0.733–0.830) | 0.781 (0.733–0.830) | ||||
Pack-years + GRS | 0.779 (0.730–0.827) | 0.777 (0.728–0.826) | 7.5 | 0.0146 | 0.86 | 0.0082 |
Pack-years + MRS | 0.813 (0.767–0.859) | 0.812 (0.766–0.858) | 12.3 | 0.0355 | 1.99 | 0.0157 |
Pack-years + GRS + MRS | 0.813 (0.767–0.859) | 0.810 (0.764–0.857) | 13.9 | 0.0198 | 2.59 | 0.0012 |
Ever smokersc | ||||||
GRS | 0.593 (0.536–0.649) | 0.592 (0.536–0.649) | ||||
MRS | 0.696 (0.642–0.751) | 0.696 (0.641–0.751) | ||||
GRS + MRS | 0.721 (0.667–0.775) | 0.717 (0.663–0.770) | ||||
Pack-years | 0.702 (0.644–0.759) | 0.701 (0.644–0.759) | ||||
Pack-years + GRS | 0.708 (0.651–0.765) | 0.705 (0.647–0.762) | 12.7 | 0.0097 | 1.39 | 0.0059 |
Pack-years + MRS | 0.731 (0.675–0.787) | 0.728 (0.672–0.784) | 16.6 | 0.0100 | 1.89 | 0.0104 |
Pack-years + GRS + MRS | 0.743 (0.687–0.798) | 0.737 (0.681–0.792) | 16.6 | 0.0163 | 2.96 | 0.0002 |
Heavy smokersd | ||||||
GRS | 0.574 (0.494–0.654) | 0.571 (0.491–0.650) | ||||
MRS | 0.629 (0.550–0.707) | 0.628 (0.549–0.707) | ||||
GRS + MRS | 0.649 (0.570–0.727) | 0.635 (0.556–0.714) | ||||
Pack-years | 0.605 (0.525–0.684) | 0.605 (0.525–0.684) | ||||
Pack-years + GRS | 0.619 (0.540–0.698) | 0.610 (0.531–0.690) | 14.5 | 0.0598 | 1.52 | 0.0456 |
Pack-years + MRS | 0.662 (0.584–0.740) | 0.652 (0.574–0.730) | 19.4 | 0.0357 | 2.13 | 0.0322 |
Pack-years + GRS + MRS | 0.672 (0.595–0.749) | 0.654 (0.576–0.732) | 26.7 | 0.0106 | 3.35 | 0.0036 |