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Table 2 Differential methylation regions corresponding genes and β values of diabetic retinopathy and nondiabetic retinopathy subjects in the discovery study

From: Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (≥ 30 years) type 2 diabetes without diabetic retinopathy

DMR

Gene

β value

P value

DR group

Non-DR group

Difference

TSS1500

MDFI

0.414024

0.554308

− 0.140284

0.000962

PGBD5

0.538043

0.365315

0.17273

0.000358

TSS200

ADRA2C

0.042839

0.27238

− 0.229541

0.002349

UTR5

CNTNAP5

0.256273

0.445609

− 0.189336

0.012985

EXON1

PRSS23

0.027501

0.168661

− 0.14116

0.018082

S100A13

0.509213

0.660521

− 0.151308

1.1E−05

TIGD5

0.112166

0.27952

− 0.167354

0.001071

GENE BODY

COQ3

0.463529

0.637303

− 0.173774

0.021585

MOSC2

0.451381

0.634923

− 0.183542

0.00509

UTR3

FLVCR1

0.442131

0.619624

− 0.177493

0.048598

HLA-B

0.088913

0.308803

− 0.21989

0.001479

RRH

0.800984

0.629198

0.17179

0.003695

ISLAND

chr1:19110720-19110932

0.56494

0.708782

− 0.143842

0.038852

chr15:22982192-22982410

0.93844

0.771584

0.16686

0.035381

NSHELF

chr12:120933649-120934713

0.376657

0.609267

− 0.23261

0.026168

chr14:105603310-105603532

0.730847

0.544063

0.18678

0.03281

chr17:35165323-35165983

0.636466

0.394896

0.24157

0.009788

chr18:21083161-21084153

0.890993

0.690135

0.20086

0.008755

chr4:4119800-4120035

0.5605

0.294444

0.26606

0.017018

chr4:47427692-47427905

0.54905

0.703312

− 0.154262

0.04677

chr4:81951941-81952808

0.65228

0.810351

− 0.158072

0.026402

NSHORE

chr5:178565716-178565918

0.721065

0.861094

− 0.140029

0.008616

SSHELF

chr1:219786334-219786562

0.218291

0.432222

− 0.213931

0.00867

chr13:26586287-26586761

0.603417

0.764495

− 0.161078

0.039872

chr14:71108008-71109332

0.876179

0.589911

0.28627

0.00262

chr16:25268786-25269728

0.878063

0.59304

0.28502

0.001536

chr1:6761295-6762131

0.719637

0.559159

0.16048

0.011819

chr16:85305690-85305892

0.365183

0.543685

− 0.178502

0.045519

chr22:20459267-20461473

0.495691

0.667066

− 0.171375

0.037325

chr2:8825106-8826188

0.724995

0.875096

− 0.1501

0.025348

chr4:120987617-120988156

0.859063

0.656103

0.20296

0.000565

SSHORE

chr10:54631211-54631426

0.480326

0.686335

− 0.206009

0.006475

chr1:19110720-19110932

0.547506

0.705954

− 0.158447

0.002265

chr6:169195967-169196186

0.577833

0.762515

− 0.184682

0.010715

  1. DMR differentially methylated region, DR diabetic retinopathy, TSS transcriptional start site, UTR untranslated region, MDFI MyoD family inhibitor, PGBD5 piggyBac transposable element derived 5, ADRA2Cadrenoceptor alpha 2C, CNTNAP5 contactin-associated protein-like 5, PRSS23serine protease 23, S100A13calcium-binding protein A13, TIGD5tigger transposable element derived 5, COQ3coenzyme Q3 methyltransferase, MOSC2mitochondrial amidoxime-reducing component 2, FLVCR1feline leukemia virus sub-group C cellular receptor 1, HLA-Bmajor histocompatibility complex, class I B, RRH retinal pigment epithelium-derived rhodopsin homolog
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Clinical Epigenetics

ISSN: 1868-7083

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