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Table 1 The basic and clinical characteristics of the 19 diabetic retinopathy patients (type 2 diabetes mellitus duration of < 3 years) and 21 patients with no sign of diabetic retinopathy with a type 2 diabetes mellitus duration of > 30 years enrolled in the discovery study

From: Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (≥ 30 years) type 2 diabetes without diabetic retinopathy

Characteristics*

DR group

Non-DR group

P value#

Number

19

21

/

Sex (male)

10

10

1

Age (year)

68.74 ± 8.69

74.19 ± 8.59

0.05

Age of DM onset (year)

67.26 ± 8.59

40.10 ± 9.13

0.00

DM duration (year)

1.47 ± 1.07

34.09 ± 5.74

/

Blood glucose (mmol/L)

6.95 ± 1.94

6.99 ± 2.22

0.93

HbA1c (%)

6.79 ± 1.26

7.53 ± 1.44

0.04

BMI (kg/m2)

25.30 ± 4.55

24.94 ± 3.33

0.94

MAP (mmHg)

102.98 ± 12.53

103.37 ± 13.45

0.93

SER (D)

− 0.53 ± 2.06

0.17 ± 2.01

0.24

IOP (mmHg)

13.80 ± 4.24

15.02 ± 2.62

0.28

AL (mm)

23.23 ± 1.13

23.26 ± 0.86

0.93

  1. DR diabetic retinopathy, T2DM type 2 diabetes mellitus
  2. *BMI body mass index; MAP (mmHg) mean arterial pressure, equal to (systolic pressure + 2*diastolic pressure)/3; SER (D) spherical equivalent rate, equal to spherical power + 1/2 cylindrical power; IOP: intraocular pressure; AL: axial length.
  3. #X2 Chi-square test, t Student’s t test, Z Mann-Whitney test