TY - JOUR AU - Damaschke, Nathan A. AU - Gawdzik, Joseph AU - Avilla, Mele AU - Yang, Bing AU - Svaren, John AU - Roopra, Avtar AU - Luo, Jian-Hua AU - Yu, Yan P. AU - Keles, Sunduz AU - Jarrard, David F. PY - 2020 DA - 2020/06/05 TI - CTCF loss mediates unique DNA hypermethylation landscapes in human cancers JO - Clinical Epigenetics SP - 80 VL - 12 IS - 1 AB - The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigenetic states through barrier insulation, the impact of CTCF loss on genome-wide DNA methylation sites in human cancer remains undefined. SN - 1868-7083 UR - https://doi.org/10.1186/s13148-020-00869-7 DO - 10.1186/s13148-020-00869-7 ID - Damaschke2020 ER -