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Table 4 Mean methylation in the OPRM1 promoter and association with opioid dose and days of use

From: Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter

 

MME dosage effect visit 32

Days of opioid use effect visit 32

Coef

t val

p (one-tailed)

Coef

t val

p (one-tailed)

Promoter methylation 1

0.0002

2.16

0.02

0.003

3.40

0.001

  1. 1OPRM1 promoter methylation summarize by averaging the β values for CpG1 to CpG9
  2. 2Linear regression at visit 3, one-tailed p value to test hypermethylation with higher cumulative MME or longer duration of use