BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27

Table 2 ZBTB16 methylation and clinicopathological features of breast tumors

Clinicopathological features	Number (n = 152)	Methylated status		p value
Clinicopathological features	Number (n = 152)	Unmethylated	Methylated	p value
Age
≤ 40	24	12	12	0.833
> 40	128	67	61	0.833
Grade
I	10	3	7	0.123
II	102	50	52
III	9	7	2
Unknown	31	19	12
Tumor size
< 2.0 cm	43	17	26	0.277
≥ 2.0 cm, <5.0 cm	85	49	36
≥ 5.0 cm	18	10	8
Unknown	6	3	3
Lymph node metastasis
Positive	72	39	33	0.664
Negative	72	37	35	0.664
Unknown	8	3	5
ER
Positive	84	43	41	0.977
Negative	51	27	24	0.977
Unknown	17	9	8
PR
Positive	67	37	30	0.653
Negative	67	32	35	0.653
Unknown	18	10	8
HER2
Positive	107	54	53	0.736
Negative	25	13	12	0.736
Unknown	20	12	8
Distant metastasis
Positive	2	0	2	0.072
Negative	139	76	63	0.072
Unknown	11	3	8
p53
Positive	64	32	32	0.574
Negative	51	25	26	0.574
Unknown	37	22	15

ISSN: 1868-7083