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Fig. 3 | Clinical Epigenetics

Fig. 3

From: BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27

Fig. 3

ZBTB16 inhibits breast cancer cells growth in vitro. a Detection of ZBTB16 overexpression by RT-PCR (upper panel) and Western blot (lower panel), with GAPDH as a control. Ectopic expression of ZBTB16 inhibited carcinoma cell growth, as assessed by CCK8 (b), colony formation (c), or soft agar assays (d).Values were shown as mean ± standard error from three independent experiments. e Cell cycle distribution of vector- or ZBTB16-transfected cells as determined by flow cytometry. Representative flow cytometry plots. Histograms of cell cycle alterations. f Induction of apoptosis detected by flow cytometry. Histograms of apoptosis rate were shown at the right. Values were shown as mean ± standard error from three independent experiments. **p < 0.01; ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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