Table 1 ADNI patient cohort selected for DNA methylation analysis and used for final analysis after normalization and quality control
Starting Patient Cohort (N=653; 1720 DNA samples) | |||||
Diagnosis Groups | Age in years Mean (SD) | Number of Males (%) | Number APOE e4 positive (%) | ||
Cognitively Normal (n=223) | 76.23 (6.7) | 112 (50.2%) | 58 (26%) | ||
Mild Cognitive Impairment (n=336) | 72.58 (7.82) | 189 (56.3%) | 153 (46%) | ||
Alzheimer's Disease (n=94) | 77.19 (7.69) | 60 (63.8%) | 64 (68%) | ||
After Normalization , Quality Control and Removal of Replicates (total 1707) | |||||
Diagnosis at 1st Visit | Number at Visit 1 | Number at Visit 2 | Number at Visit 3 | Number at Visit 4 | Number at Visit 5 |
Cognitively Normal | 220 | 200 | 162 | 15 | 4 |
Mild Cognitive Impairment | 333 | 312 | 235 | 23 | 4 |
Alzheimer’s Disease | 94 | 53 | 51 | - | - |