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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Harnessing peripheral DNA methylation differences in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

Fig. 4

Comparison of DNA methylation in AD (Alzheimer’s disease) vs MCI (mild cognitive impairment). a Manhattan plot showing the top hits in the AD vs MCI comparison. The blue line indicates p value threshold of 1 × 10−5 and the red line indicates p value threshold of 1 × 10−7. b Distribution of unadjusted M values in NUCB2, the top DMP across CN (green), MCI (blue), and AD (red). Violin plots outline the spread of the data. c Correlation of MMSE scores with differential methylation at the NUCB2 locus

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