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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Harnessing peripheral DNA methylation differences in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

Fig. 3

Comparison of DNA methylation in MCI (Mild cognitive impairment) vs CN (cognitively normal). a Manhattan plot showing the top hits in the MCI vs CN comparison. The blue line indicates p value threshold of 1 × 10−5 and the red line indicates p value threshold of 1 × 10−7. b Distribution of unadjusted M values in CLIP4, the top DMP across CN (green), MCI (blue), and AD (red). Violin plots outline the spread of the data. c Correlation of MMSE scores with differential methylation at the CLIP4 locus.

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Clinical Epigenetics

ISSN: 1868-7083

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