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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Harnessing peripheral DNA methylation differences in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

Fig. 2

Comparison of DNA methylation in AD (Alzheimer’s disease) vs CN (cognitively normal). a Manhattan plot showing the top hits in the AD vs CN comparison. The blue line indicates p value threshold of 1 × 10−5 and the red line indicates p value threshold of 1 × 10−7. b Distribution of unadjusted M values in FAM8A1, the top DMP across CN (green), MCI (blue), and AD (red). Violin plots outline the spread of the data. c Correlation of MMSE scores with differential methylation at the FAM8A1 locus

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Clinical Epigenetics

ISSN: 1868-7083

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