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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Harnessing peripheral DNA methylation differences in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

Fig. 1

Distribution of cross-diagnosis differential DNA methylation marks across the genome. a–c Distribution of differential DNA methylation marks relative to the CpG island. Islands are denoted by yellow, shelves (regions 2–4 kb from CpG Islands) by purple, shores (regions 0–2 kb from CpG Islands) by blue and the open seas (genomic loci that fall outside of the islands, shelves, and shores) by orange. Percentages are calculated as percent total number of hits. d Distribution of differential DNA methylation marks across different genomic loci. Annotations of the locations are obtained from Illumina EPIC manifests: TSS1500 = within 1500 bp of transcription start site (TSS); TSS200 = within 200 bp of TSS

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Clinical Epigenetics

ISSN: 1868-7083

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