Fig. 2

EZH2 regulates glutamine metabolism by silencing BCAT1 transcription through catalyzing H3K27me3. a BCAT1 is repressed by EZH2-PRC2 mediated H3K27me3 in normal hematopoietic processes. b BCAT1 is abnormally activated in EZH2-deficient myeloid neoplasms and EZH2 inactivated leukemia stem cells