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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect

Fig. 5

A schematic representation of the role of adipocyte turnover in health and disease. In healthy individuals, preadipocytes differentiate into mature adipocytes, which have a role in maintaining insulin sensitivity. However, in response to statins, epigenetic changes in HDAC9 cause acetylation changes in ABCG1 and other crucial adipogenesis genes, which in-turn lead to an obstruction of differentiation and metabolic dysfunction

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