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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect

Fig. 2

Methylome analysis of statin-treated SGBS cells. a Volcano plots of methylome results for statin-treated cells (grey indicates log2 fold change < 1). b The hypomethylation of the cg14566882 CpG within the HDAC9 gene in atorvastatin and mevastatin-treated cells compared to vehicle-treated DMSO cells in the 4 biological replicates (raw Ī²-values shown). c The mRNA expression level of HDAC9 in mevastatin and atorvastatin-treated SGSB cell line. *p < 0.05; **p < 0.01. d The protein expression of ABCG1 compared to housekeeping gene p84 shows a reduced expression in atorvastatin and mevastatin-treated SGBS cells. e ChIP qPCR using anti-HDAC9 antibody for the ABCG1 promoter for control (DMSO), mevastatin and atorvastatin-treated cells, normaled to no antibody (mock IgG) control. This experiment was performed in two biological replicates

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Clinical Epigenetics

ISSN: 1868-7083

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