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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes

Fig. 2

Changes in the CpG methylation landscape from gametes to blastocyst in pig and cow. Screenshot of Seqmonk genome browser at regions of conserved synteny in porcine chromosome 17 (a) and bovine chromosome 13 (b) centred on the GNAS locus. For the profiles for each stage, each vertical bar represents the methylation value of a single, non-overlapping 100-CpG tile, with methylation indicated by the height of the bar and the colour-coding. At the top, the track ‘gene’ indicates the location of genes, with those marked red being transcribed from left to right, and those marked blue from right to left; HyperDomains (HyperD) and HypoDomains (HypoD) are indicated by bar bars. Histograms of the percentage of 100-CpG windows binned according to the given methylation levels in porcine (c) and bovine (d) samples. The data in c are based on 253122 informative 100-CpG windows and in d on 256422 100-CpG windows

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Clinical Epigenetics

ISSN: 1868-7083

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