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Table 2 Cox proportional hazard model of clinical parameters and TMEM240 mRNA expression level associated with Taiwan CRC patients

From: Hypermethylation and decreased expression of TMEM240 are potential early-onset biomarkers for colorectal cancer detection, poor prognosis, and early recurrence prediction

 

Multivariate analysis

 

Variable

HR

95% CI

p value

Lower

Upper

Overall survival

 Age

0.291

0.051

1.667

0.166

 Sex

0.308

0.054

1.740

0.182

 Stage

4.702

1.695

13.041

0.003

 Location

2.970

0.985

8.951

0.053

 Differentiation

0.599

0.030

11.897

0.737

 DNA methylation

1.005

1.001

1.010

0.028

 mRNA expression

0.196

0.055

0.704

0.012

Cancer specific survival

 Age

0.198

0.025

1.584

0.127

 Sex

0.245

0.035

1.718

0.157

 Stage

7.658

2.083

28.161

0.002

 Location

4.055

1.257

13.083

0.019

 Differentiation

0.463

0.017

12.307

0.646

 DNA methylation

1.006

1.001

1.011

0.025

 mRNA expression

0.142

0.035

0.587

0.007

Recurrence-free survival

 Age

0.360

0.088

1.473

0.155

 Sex

0.358

0.095

1.345

0.128

 Stage

9.385

3.249

27.112

< 0.000

 Location

2.338

0.941

5.809

0.067

 Differentiation

0.873

0.143

5.338

0.883

 DNA methylation

1.004

1.000

1.008

0.045

 mRNA expression

0.289

0.100

0.837

0.022

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Clinical Epigenetics

ISSN: 1868-7083

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