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Table 1 Alterations of TMEM240 in relation to the clinical parameters of Taiwan CRC cancer

From: Hypermethylation and decreased expression of TMEM240 are potential early-onset biomarkers for colorectal cancer detection, poor prognosis, and early recurrence prediction

Characteristics

Total na

TMEM240 methylationb

Total n

TMEM240 mRNAc

Total n

TMEM240 protein

Low n (%), high n(%)

Low n (%), high n (%)

Low n (%), high n (%)

Overall

556

71

(12.8)

485

(87.2)

127

89

(70.1)

38

(29.9)

179

131

(73.6)

47

(26.4)

CRC

547

67

(12.2)

480

(87.8)

118

85

(72.0)

33

(28.0)

141

124

(87.9)

17

(12.1)

Age

 < 65

240

28

(11.7)

212

(88.3)0.736

44

29

(66.9)

15

(34.1)0.158

132

96

(72.7)

36

(27.3)0.656

> 65

285

36

(12.6)

249

(87.4)

60

47

(73.1)

13

(26.9)

46

35

(76.1)

11

(23.9)

Sex

 Male

312

41

(13.1)

271

(86.9)0.409

57

37

(64.9)

20

(35.1)0.084

120

89

(74.2)

31

(25.8)0.672

 Female

214

23

(10.7)

181

(89.3)

54

43

(79.6)

11

(20.4)

59

42

(71.2)

17

(28.8)

Tumor type

 Adeno

491

58

(11.8)

433

(88.2)0.357

103

76

(73.8)

27

(26.2)0.266

90

84

(93.3)

6

(6.7)0.189

 Others

56

9

(16.1)

47

(83.9)

15

9

(60.0)

6

(40.0)

19

16

(84.2)

3

(15.8)

Tumor stage

 0 and I

53

11

(20.8)

42

(79.2)0.043

9

8

(77.8)

1

(22.2)0.238

6

6

(100.0)

0

(0.0)0.450

 II, III, and IV

449

50

(11.1)

399

(88.9)

98

69

(70.4)

29

(29.6)

103

94

(91.3)

9

(8.7)

Tumor size

 T0–T1

34

4

(11.8)

30

(88.2)0.938

5

4

(80.0)

1

(20.0)0.664

10

10

(100.0)

0

(0.0)0.320

 T2–T4

483

59

(12.2)

424

(87.8)

100

71

(71.0)

29

(29.0)

99

90

(90.9)

9

(9.1)

Regional lymph nodes metastasis

 N = 0

269

29

(10.8)

240

(89.2)0.309

56

40

(71.4)

16

(28.6)0.897

63

59

(93.7)

4

(6.3)0.397

 N > 1

248

34

(13.7)

214

(86.3)

51

37

(72.5)

14

(27.5)

46

41

(89.1)

5

(10.9)

Distant metastasis

 M = 0

396

45

(11.4)

351

(88.6)0.235

76

55

(72.4)

21

(27.6)0.788

92

85

(92.4)

7

(7.6)0.026

 M > 1

102

16

(15.7)

86

(84.3)

28

21

(75.0)

7

(25.0)

49

39

(79.6)

10

(20.4)

Differentiation grade

 Well/moderate

479

59

(21.4)

420

(87.7)0.583

100

73

(73.0)

27

(27.0)0.577

91

83

(91.2)

8

(8.8)0.448

 Poor

33

3

(9.1)

30

(90.9)

6

5

(83.3)

1

(16.7)

6

6

(100.0)

0

(0.0)

Location

 Cecum, appendix

47

3

(6.4)

44

(93.6)0.449

8

6

(75.0)

2

(25.0)0.891

5

5

(100.0)

0

(0.0)0.097

 Ascending colon

88

9

(10.2)

79

(89.8)

10

8

(80.0)

2

(20.0)

21

20

(95.2)

1

(4.8)

 Transverse colon

24

2

(8.3)

22

(91.7)

6

4

(66.7)

2

(33.3)

10

7

(70.0)

3

(30.0)

 Descending colon

47

9

(6.4)

38

(80.9)

9

5

(55.6)

4

(44.4)

9

8

(88.9)

1

(11.1)

 Sigmoid colon

161

20

(12.4)

141

(87.6)

27

18

(66.7)

9

(33.3)

31

30

(96.8)

1

(3.2)

 Rectum

129

13

(10.1)

116

(89.9)

15

11

(73.3)

4

(26.7)

20

19

(95.0)

1

(5.0)

Vascular invasion

 No invasion

407

49

(12.0)

358

(88.0)0.458

59

43

(72.9)

16

(27.1)0.956

     

 Invasion

77

7

(9.1)

70

(90.9)

18

13

(72.2)

5

(27.8)

     

MSI

 MSS

50

3

(6.0)

47

(94.0)0.419

37

27

(73.0)

10

(27.0)0.630

     

 MSI-L

6

1

(16.7)

5

(83.3)

5

3

(60.0)

2

(40.0)

     

 MSI-H

9

0

(0.0)

9

(100.0)

7

4

(57.1)

3

(42.9)

     

Tissue types

 Malignant

          

109

100

(91.7)

9

(8.3)< 0.001

 Metastasis

          

32

24

(75.0)

8

(25.0)

 Benign tumor

9

4

(44.4)

5

(55.6)

9

4

(44.4)

5

(55.6)

10

3

(30.0)

7

(70.0)

 Hyperplasia

          

8

1

(12.5)

7

(87.5)

 Inflammation

          

10

5

(50.0)

5

(50.0)

 Adjacent normal

          

11

5

(45.5)

6

(54.5)

 Normal colon

          

8

2

(25.0)

6

(75.0)

  1. These results were analyzed by the Pearson X2 test. Significant p values are indicated by superscripts
  2. aFor some categories, the number of samples (n) was lower than the overall number analyzed because clinical data were unavailable for those samples
  3. bThe TMEM240 promoter methylation level in CRC tumors being 5-fold higher than in adjacent normal colorectal tissues was defined as hypermethylation
  4. cThe TMEM240 expression level in CRC tumors being less than that of adjacent normal colorectal tissues was defined as low expression
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Clinical Epigenetics

ISSN: 1868-7083

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