Table 1 Cumulative incident risk of CIN3+ and HPV16 positivity frequency by the numbers of high-methylation sites of HPV 16
HPV gene | Numbers of sites* | Numbers of individual | 10-year cumulative CIN3+ | HPV16 positivity frequency# | |||||
|---|---|---|---|---|---|---|---|---|---|
Incidence rate | HR (95%CI) | p§ | Once | Twice | Three times | p†| |||
L1 | 0 | 26 | 7.7 (2.1, 24.1) | 1 (Ref.) | < 0.001 | 76.9 (58.0, 89.0) | 19.2 (8.5, 37.9) | 3.8 (0.7, 18.9) | < 0.001 |
1 | 28 | 21.4 (10.2, 39.5) | 3.3 (0.7, 16.5) | Â | 40.0 (23.4, 59.3) | 20.0 (8.9, 39.1) | 40.0 (23.4, 59.3) | Â | |
2–3 | 8 | 75.0 (40.9, 92.9) | 14.6 (2.9, 74.6) |  | 25.0 (7.1, 59.1) | 0 (0, 32.4) | 75.0 (40.9, 92.9) |  | |
LCR | 0 | 29 | 6.9 (1.9, 22.0) | 1 (Ref.) | 0.001 | 55.2 (37.6, 71.6) | 20.7 (9.8, 38.4) | 24.1 (12.2, 42.1) | 0.296 |
1 | 21 | 23.8 (10.6, 45.1) | 3.9 (0.8, 20.2) | Â | 63.2 (41.0, 80.9) | 10.5 (2.9, 31.4) | 26.3 (11.8, 48.8) | Â | |
2–3 | 12 | 58.3 (32.0, 80.7) | 12.8 (2.6, 62.5) |  | 36.4 (15.2, 64.6) | 18.2 (5.1, 47.7) | 45.5 (21.3, 72.0) |  | |
L1+LCR | 0 | 14 | 0 (0, 21.5) | --- | Â | 71.4 (45.4, 88.3) | 21.4 (7.6, 47.6) | 7.1 (1.3, 31.5) | 0.004 |
1 | 22 | 9.1 (2.5, 27.8) | 1 (Ref.) | < 0.001 | 59.1 (38.7, 76.7) | 18.2 (7.3, 38.5) | 22.7 (10.1, 43.4) | Â | |
2 | 14 | 28.6 (11.7, 54.7) | 3.7 (0.7, 20.0) | Â | 50.0 (25.4, 74.6) | 16.7 (4.7, 44.8) | 33.3 (13.8, 60.9) | Â | |
3–6 | 12 | 66.7 (39.1,86.2) | 12.0 (2.5,57.7) |  | 27.3 (9.7,56.6) | 9.1 (1.6,37.7) | 63.6 (35.4,84.8) |  | |