Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

Table 3 Meta-analysis of first trimester CRP and newborn methylation in four cohorts

CpG Site	Effect	SE	p value*	Direction**	Het. p value	Chr: position
cg19858671	0.0041	8.00E−04	1.21E-06	++?+	0.83	8: 130951373
cg06320401	− 0.0092	0.0019	1.50E-06	----	0.74	1: 48176755
cg22649187	− 0.0069	0.0015	3.56E-06	----	0.88	11: 48176755
cg04747517	− 0.0022	5.00E−04	3.89E-06	----	0.73	3: 169755595
cg05986933	− 0.0042	9.00E−04	4.11E-06	----	0.84	2: 43020457

SE standard error, Het heterogeneity, chr chromosome
*All FDR p values < 0.5 (non-significant) and were adjusted for maternal age, race (as applicable), socioeconomic income (by education, income, or other cohort specific factors), maternal BMI and smoking, and cell type distribution [21] (Model 2)
**Direction of associations for each cohort in the following order: GenR, PREDO, INMA, EAGeR; the “?” is due this CpG being excluded from analysis in INMA after data cleaning steps

ISSN: 1868-7083