Clinical Epigenetics

Table 1 Prediction performance based on hyper-DMS and hypo-DMS to distinguish between disease and normal colorectal tissues

From: Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma

Model	Methylation	Observation	Prediction		Sensitivity	Specificity
Model	Methylation	Observation	Disease	Normal	Sensitivity	Specificity
Random forest	Hyper	Disease	532	23	0.959	0.860
	Hyper	Normal	39	239	0.959	0.860
	Hypo	Disease	507	48	0.914	0.601
	Hypo	Normal	111	167	0.914	0.601
Neural network	Hyper	Disease	537	18	0.968	0.727
	Hyper	Normal	76	202	0.968	0.727
	Hypo	Disease	406	149	0.732	0.701
	Hypo	Normal	83	195	0.732	0.701

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ISSN: 1868-7083

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