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Table 1 Prediction performance based on hyper-DMS and hypo-DMS to distinguish between disease and normal colorectal tissues

From: Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma

ModelMethylationObservationPredictionSensitivitySpecificity
DiseaseNormal
Random forestHyperDisease532230.9590.860
Normal39239
HypoDisease507480.9140.601
Normal111167
Neural networkHyperDisease537180.9680.727
Normal76202
HypoDisease4061490.7320.701
Normal83195