Table 6 Proportions of phenotypic variance explained by the DNAm risk scores employed
Methylation score | Variance explained in phenotype |
|---|---|
Smoking | |
 Trejo Bayesian (59 CpG sites) | 48.7% |
AHRR (cg05575921) | 47.0% |
 McCartney LASSO (233 CpG sites) | 43.5% |
 Joehanes (Bonferroni) (2623 CpG sites) | 40.5% |
 Joehanes (FDR) (18,670 CpG sites) | 33.5% |
 Zhang (4 CpG sites) | 5.2% |
Alcohol | |
 Liu model 4 (144 CpG sites) | 16.5% |
 Liu model 3 (78 CpG sites) | 15.8% |
 Liu model 1 (5 CpG sites) | 13.9% |
 Liu model 2 (23 CpG sites) | 10.3% |
 McCartney LASSO (450 CpG sites) | 10.0% |
BMI | |
 Trejo Bayesian (144 CpG sites) | 24.5% |
 McCartney LASSO (1109 CpG sites) | 22.2% |
Educational attainment | |
 McCartney LASSO (373 CpG sites) | 0.4% |